Apoptosis Induction, Cell Cycle Arrest and Anti-Cancer Potential of Tamoxifen-Curcumin Loaded Niosomes Against MCF-7 Cancer Cells

Background & Objective: Breast cancer is the most common among women. One of effective treatments for breast chemotherapy, in which specific drugs destroy mass and its proliferation inhibited. Chemotherapy adjunctive therapy when multiple medications are used concurrently. Also, combining with nanocarrier has become an important strategy targeted therapy. This study designed to assess apoptosis induction, cell cycle arrest, anti-cancer potential Tamoxifen-Curcumin-loaded niosomes against MCF-7 Cancer Cells.Methods: A novel niosomal formulation tamoxifen-curcumin Span 80 lipid drug ratio 20 was employed. The cells were cultured then treated IC50 value tamoxifen-curcumin-loaded niosomes, combination tamoxifen curcumin, tamoxifen, curcumin alone. Flow cytometry, Real-Time PCR, analysis tests conducted evaluate induction apoptosis.Results: Drug-loaded caused up-regulation bax p53 genes down-regulation bcl2 gene. cytometry studies showed that containing increased rate compared owing synergistic effect between two along higher uptake by niosomal. These results also confirmed analysis.Conclusion: Co-delivery using optimized revealed at acidic pH cells, released from carriers would be more than physiological pH. feature nanoparticles can reduce side effects normal cells. Niosomal might as a biological factor treatment cancer.